Artemisinin–acetylenedicarboxylic acid cocrystal: screening, structure determination, and physicochemical property characterisation

Structure and physicochemical characterization of a naproxen–picolinamide cocrystal

Naproxen (NPX) is a nonsteroidal anti-inflammatory drug with pain- and fever-relieving properties, currently marketed in the sodium salt form to overcome solubility problems; however, alternative solutions for improving its solubility across all pH values are desirable. NPX is suitable for cocrystal formation, with hydrogen-bonding possibilities via the COOH group. The crystal structure is pres...

Synthesis , structure determination , and formation of a theobromine : oxalic acid 2 : 1 cocrystal †

824 | CrystEngComm, 2015, 17, 824–829 This journal is © The R a BAM Federal Institute for Materials Research and Testing, Richard-WillstaetterStr. 11, 12489 Berlin, Germany. E-mail: [email protected] Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany † Electronic supplementary information (ESI) available: DTA-TGA measurements of the reac...

Protein Folding Recognition Based on Amino Acid Physicochemical Property Profiles

Differentiating physicochemical property: Chemical composition

BBB blood-brain barrier BMEC brain microvascular (capillary) endothelial cells CBSA cationic bovine serum albumin CdTe cadmium tellurium CTAB trimethylammonium bromide DRG dorsal root ganglia HSA human serum albumin ip intraperitoneal iv intravenous MWCNT multi-walled carbon nanotube PAMAM poly(amidoamine) PBCA polybutylcyanoacrylate PEG polyethylene glycol PLA poly(lactide) PLGA poly(lactic-co...

Structure Property Relationships of Carboxylic Acid Isosteres

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying principle is that by maintaining the features of the carboxylic acid critical for biological activity, but appropriately modifying the physicochemical properties, improved analogs may result. In this context, a systematic assessment of the ph...